3D生物打印脱细胞脐带基质贴片用于增强TMSC-EVs在糖尿病创面愈合中的递送

核心信息

论文英文标题: A 3D-Bioprinted Decellularized Umbilical Cord Matrix Patch for Enhanced Storage and Deliveryof Extracellular Vesicles in Diabetic Wound Healing
期刊: Research
发表年份: 2026
DOI: 10.34133/research.1246
PMID/PMCID: 42027992; PMC13100348

研究概览

Herein, we developed a 3-dimensional bioprinted methacrylated decellularized umbilical cord matrix (MDUM) patch enabling the sustained delivery of telomerase-immortalized umbilical cord mesenchymal stem cell-derived EVs (TMSC-EVs). In a diabetic murine wound model, our data demonstrated that MDUM could enhance the retention and delivery of TMSC-EVs and further augment the therapeutic effects for diabetic wound healing as revealed by attenuating proinflammatory cytokine levels, enhancing neovascularization, and accelerating collagen deposition.

核心发现

Extracellular vesicles (EVs) are promising cell-free therapeutics for diabetic wound healing due to their immunomodulatory and proangiogenic properties.

Nonetheless, challenges in ensuring long-term stability and achieving targeted delivery continue to impede clinical translation.

In a diabetic murine wound model, our data demonstrated that MDUM could enhance the retention and delivery of TMSC-EVs and further augment the therapeutic effects for diabetic wound healing as revealed by attenuating proinflammatory cytokine levels, enhancing neovascularization, and accelerating collagen deposition.

Echo Biotech 角色

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: A 3D-Bioprinted Decellularized Umbilical Cord Matrix Patch for Enhanced Storage and Deliveryof Extracellular Vesicles in Diabetic Wound Healing Research. 2026. DOI: 10.34133/research.1246. PMID/PMCID: 42027992; PMC13100348.