脂肪细胞衍生的外泌体MTTP抑制结直肠癌的铁死亡并促进化疗耐药

核心信息

• 论文英文标题: Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer
• 期刊: Adv Sci
• 发表年份: 2022
• DOI: 10.1002/advs.202203357
• PMID/PMCID: 35978266; PMC9534973

研究概览

Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. The results reveal a novel intracellular signaling pathway mediated by adipose-derived exosomes and suggest that treatments targeting secreted MTTP might reverse oxaliplatin resistance in CRC.

核心发现

Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear.

Ferroptosis is a form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS) accumulation and iron dependency and is associated with the chemoresistance of tumors.

Here, it is shown that adipose-derived exosomes reduce ferroptosis susceptibility in CRC, thus promoting chemoresistance to oxaliplatin.

It is found that microsomal triglyceride transfer protein (MTTP) expression is increased in the plasma exosomes of CRC patients with a high body fat ratio, serving as an inhibitor of ferroptosis and reducing sensitivity to chemotherapy.

Echo Biotech 角色

细胞上清外泌体分离及nanoFCM鉴定

关联平台: Exoomics®

关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer Advanced Science. 2022. DOI: 10.1002/advs.202203357. PMID/PMCID: 35978266; PMC9534973.