脂肪细胞sEV衍生的miRNA-30a-3p加剧高脂饮食喂养的雄性小鼠的肝脏脂肪变性

核心信息

• 论文英文标题: Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepatic steatosis in high fat diet-fed male mice
• 期刊: Nat Commun
• 发表年份: 2026
• DOI: 10.1038/s41467-026-71731-2
• PMID/PMCID: 41965824; PMC13243456

研究概览

Adipose tissue dysfunction drives hepatic lipid overload in metabolic dysfunction-associated steatotic liver disease (MASLD), yet the involvement of adipose tissue-derived small extracellular vesicles (sEVs) remains unclear. These findings highlight the critical role of adipose sEV microRNAs in driving hepatocyte lipotoxicity, and suggest miR-30a-3p inhibition as a promising MASLD therapy.

核心发现

Adipose tissue dysfunction drives hepatic lipid overload in metabolic dysfunction-associated steatotic liver disease (MASLD), yet the involvement of adipose tissue-derived small extracellular vesicles (sEVs) remains unclear.

Herein, we showed that transplanting adipose tissue from high‑fat diet (HFD)-fed male mice exacerbated insulin resistance and hepatic steatosis in lean recipients.

Adipose‑specific Sirt3 overexpression (Sirt3AKI) alleviated insulin resistance and liver steatosis in HFD-fed male mice, whereas adipose‑specific Sirt3 knockdown aggravated these phenotypes.

Moreover, adipose sEV miRNAs regulated hepatic lipid metabolism in Sirt3AKI male mice.

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参考文献

原始论文: Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepatic steatosis in high fat diet-fed male mice Nature communications. 2026. DOI: 10.1038/s41467-026-71731-2. PMID/PMCID: 41965824; PMC13243456.