果蝇脂肪组织外泌体circ_sxc通过抑制脑dme-miR-87-3p介导脂肪体对脑衰老的调节
核心信息
- 论文英文标题: Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p
- 期刊: Mol Neurobiol
- 发表年份: 2023
- DOI: 10.1007/s12035-023-03516-3
- PMID/PMCID: 37597108; 349208
研究概览
In summary, the current study showed that the Drosophila brain could obtain circ_sxc by uptake of adipose tissue exosomes which crossed the blood-brain barrier. Adipose tissue exosomes, as adipocyte-derived vesicles, may mediate the regulatory processes of adipose tissue on other organs, including the brain; however, the regulatory mechanisms remain unclear.
核心发现
Aging of the brain usually leads to the decline of neurological processes and is a major risk factor for various neurodegenerative diseases, including sleep disturbances and cognitive decline.
Adipose tissue exosomes, as adipocyte-derived vesicles, may mediate the regulatory processes of adipose tissue on other organs, including the brain; however, the regulatory mechanisms remain unclear.
We analyzed the sleep-wake behavior of young (10 days) and old (40 days) Drosophila and found that older Drosophila showed increased sleep fragmentation, which is similar to mammalian aging characteristics.
To investigate the cross-tissue regulatory mechanisms of adiposity on brain aging, we extracted 10-day and 40-day Drosophila adipose tissue exosomes and identified circRNAs with age-dependent expression differences by RNA-seq and differential analysis.
Echo Biotech 角色
果蝇脂肪组织外泌体分离及电镜NTA鉴定 和 长链RNA组学
关联平台: Exoomics®
关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p Mol Neurobiol. 2023. DOI: 10.1007/s12035-023-03516-3. PMID/PMCID: 37597108; 349208.