包裹在MXene修饰的GelMA水凝胶中的AntagomiR-192-5p工程外泌体通过靶向OLFM4促进烧伤创面的上皮化

核心信息

• 论文英文标题: AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4
• 期刊: Bioact Mater
• 发表年份: 2025
• DOI: 10.1016/j.bioactmat.2025.06.013
• PMID/PMCID: 40575328; PMC12198005

研究概览

In this study we screened the key miRNA regulating the epithelialization process under oxidative stress conditions through high-throughput sequencing. In this study we screened the key miRNA regulating the epithelialization process under oxidative stress conditions through high-throughput sequencing.

核心发现

Burn wound healing is a multifaceted process often complicated by excessive inflammation and impaired keratinocyte function, both of which are key factors contributing to delayed healing.

In this study we screened the key miRNA regulating the epithelialization process under oxidative stress conditions through high-throughput sequencing.

We identified that miR-192-5p was significantly upregulated in both oxidative stress models of keratinocytes and burn wound tissues, with detrimental effects on keratinocyte proliferation, migration, and apoptosis.

Inhibition of miR-192-5p enhanced epidermal cell function by upregulating olfactomedin-4 (OLFM4), a key gene associated with cell proliferation, adhesion and migration.

Echo Biotech 角色

ContrExo CTE-052干细胞外泌体

关联平台: EV Materials / Reference Materials, Research Reagents & Tools

关联服务与能力: EV Material / Reference Material Supply

关联产品或试剂: ContrExo® EV Reference Material

参考文献

原始论文: AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4 Bioactive Materials. 2025. DOI: 10.1016/j.bioactmat.2025.06.013. PMID/PMCID: 40575328; PMC12198005.