动脉粥样硬化斑块EV介导平滑肌细胞表型转换并促进血管重塑：EV促进血管平滑肌细胞VSMC表型转换
核心信息
- 论文英文标题: Atherosclerotic plaque-derived extracellular vesicles mediate smooth muscle cell phenotypic switching and promote vascular remodeling : EVs promote VSMC phenotypic switching
- 期刊: Cell Mol Life Sci
- 发表年份: 2026
- DOI: 10.1007/s00018-026-06094-4
- PMID/PMCID: 41784666; PMC12979814
研究概览
BACKGROUND: Despite the use of lipid-lowering and anti-inflammatory treatments, the progression of atherosclerosis is relentless in most patients. This suggests the presence of in situ pathological factors that continuously exacerbate lesions.
核心发现
BACKGROUND: Despite the use of lipid-lowering and anti-inflammatory treatments, the progression of atherosclerosis is relentless in most patients.
This suggests the presence of in situ pathological factors that continuously exacerbate lesions.
We hypothesized that extracellular vesicles (EVs) within the atherosclerotic microenvironment might act as in situ stimulatory factors on vascular smooth muscle cells (VSMCs), thereby exacerbating atherosclerosis.
METHODS AND RESULTS: A local atherosclerosis model was induced using Ldlr knockout (Ldlr KO) rats fed a high-cholesterol diet and subjected to partial carotid ligation.
Echo Biotech 角色
斑块组织外泌体分离表征&外泌体长链RNA测序分析&ExoLoad核酸负载试剂盒&ContrExo 293F外泌体参考品CTE-061
关联平台: Exoomics®, Echosome®, EV Materials / Reference Materials, Research Reagents & Tools
关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV lncRNA/mRNA Sequencing, Small RNA / Cargo Loading, EV Material / Reference Material Supply
关联产品或试剂: ExoLoad® Nucleic Acid Loading Kit, ContrExo® EV Reference Material
参考文献
原始论文: Atherosclerotic plaque-derived extracellular vesicles mediate smooth muscle cell phenotypic switching and promote vascular remodeling : EVs promote VSMC phenotypic switching Cellular and molecular life sciences. 2026. DOI: 10.1007/s00018-026-06094-4. PMID/PMCID: 41784666; PMC12979814.