实验性脓毒症相关性脑病SAE大鼠脑组织外泌体miRNA表达谱及其与外周外泌体的比较

核心信息

• 论文英文标题: Brain-Derived Exosomal miRNA Profiles upon Experimental SAE Rats and Their Comparison with Peripheral Exosomes
• 期刊: Mol Neurobiol
• 发表年份: 2023
• DOI: 10.1007/s12035-023-03569-4
• PMID/PMCID: 37659038; 6953314

研究概览

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction secondary to body infection without overt central nervous system infection. Understanding exosomal miRNA profiles in SAE brain tissue and exploring the correlation with peripheral exosomal miRNA can contribute to a comprehensive understanding of miRNA changes in the SAE pathological process and provide the possibility of establishing early diagnostic assays.

核心发现

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction secondary to body infection without overt central nervous system infection.

Dysregulation of miRNA expression in the transcriptome can spread through RNA transfer in exosomes, providing an early signal of impending neuropathological changes in the brain.

Here, we comprehensively analyzed brain-derived exosomal miRNA profiles in SAE rats (n = 3) and controls (n = 3).

We further verified the differential expression and correlation of brain tissue, cerebrospinal fluid, and plasma exosomal miRNAs in SAE rats.

Echo Biotech 角色

大鼠脑组织外泌体分离电镜鉴定及miRNA测序分析

关联平台: Exoomics®

关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Brain-Derived Exosomal miRNA Profiles upon Experimental SAE Rats and Their Comparison with Peripheral Exosomes Mol Neurobiol. 2023. DOI: 10.1007/s12035-023-03569-4. PMID/PMCID: 37659038; 6953314.