棕色脂肪组织衍生的sEV-lncRNA-Morrbid有助于冷适应诱导的心脏保护免受极端寒冷
核心信息
- 论文英文标题: Brown Adipose Tissue-Derived sEV-lncRNA Morrbid Contributes to Cold Acclimation-Induced Cardioprotection Against Extreme Cold
- 期刊: J Lipid Res
- 发表年份: 2026
- DOI: 10.1016/j.jlr.2026.101082
- PMID/PMCID: 42320571
研究概览
This study investigated whether brown adipose tissue (BAT)-derived extracellular vesicles (BAT-EVs) contribute to CA-induced cardioprotection. These vesicles serve as an important mechanism to confer remote cardioprotection, potentially by upregulating cardiac Serpine1 and suppressing apoptosis, highlighting a potential therapeutic strategy for cold-induced injury.
核心发现
CA preserved cardiac function and integrity under -25 °C stress, and these effects were abolished by iBAT ablation.
EVs from CA mice mediate this protection by mitigating cardiomyocyte apoptosis.
Mechanistically, lncRNA Morrbid was enriched in iBAT and serum EVs after CA.
iBAT-specific Morrbid knockdown significantly attenuates EV-mediated protection.
研究设计
Mice were subjected to CA or acute cold stress.
Cardiac function was assessed using echocardiography and biomarkers.
Interscapular BAT (iBAT) ablation has confirmed the necessity of iBAT.
Echo Biotech 角色
小鼠血清外泌体长链RNA测序分析
关联平台: Exoomics®
关联服务与能力: EV lncRNA/mRNA Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Brown Adipose Tissue-Derived sEV-lncRNA Morrbid Contributes to Cold Acclimation-Induced Cardioprotection Against Extreme Cold Journal of lipid research. 2026. DOI: 10.1016/j.jlr.2026.101082. PMID/PMCID: 42320571.