利用再生新生小鼠心脏组织来源的EVs进行心脏修复
核心信息
- 论文英文标题: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles
- 期刊: Nat Commun
- 发表年份: 2025
- DOI: 10.3724/abbs.2024193
- PMID/PMCID: 39949198; PMC12247129
研究概览
Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure. This finding reveals a potential underlying mechanism for the compromised proliferative capacity of cardiomyocytes in adult mice.
核心发现
Myocardial infarction leads to cardiomyocyte loss, and the compromised proliferative capacity of cardiomyocytes after birth hinders the process of heart repair, ultimately culminating in heart failure.
Extracellular vesicles (EVs), known as cell-secreted "messengers", play a pivotal role in tissue pathophysiology.
Here, we report the novel finding that myocardial tissue-derived vesicles from mice on postnatal day 8 (P8-EVs) possess the potential to modulate cardiomyocyte proliferation.
Notably, direct administration of EVs derived from day 1 or day 8 (P1/P8) myocardial tissue does not impact neonatal cardiomyocyte proliferation or myocardial repair in mice with myocardial infarction.
Echo Biotech 角色
组织外泌体4D LFQ蛋白质组
关联平台: Exoomics®
关联服务与能力: EV Proteomics
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles Nature communications. 2025. DOI: 10.3724/abbs.2024193. PMID/PMCID: 39949198; PMC12247129.