货物定义的工程化EV能够靶向递送miRNA用于心肌梗死后的心脏修复

核心信息

  • 论文英文标题: Cargo-defined engineered vesicles enable targeted miRNA delivery for cardiac repair after myocardial infarction
  • 期刊: Biomaterials
  • 发表年份: 2026
  • DOI: 10.1016/j.biomaterials.2026.124251
  • PMID/PMCID: 42085858

研究概览

Herein, we identified miR-30d as a potential therapeutic target, exhibiting dynamic expression changes in plasma extracellular vesicles (EVs) from MI patients before and after percutaneous coronary intervention (PCI). Collectively, these findings underscore the therapeutic potential of miR-30d and establish programmable RNA-depleted, IMTP-conjugated mELVs as a safe, targeted, and effective platform for miRNA delivery in post-MI gene therapy.

核心发现

Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, and current therapeutic strategies offer limited efficacy in promoting long-term cardiac repair.

miRNAs have emerged as promising therapeutic agents owing to their capacity to modulate gene networks involved in cardiomyocyte apoptosis, mitochondrial dysfunction, and extracellular matrix (ECM) remodeling.

Herein, we identified miR-30d as a potential therapeutic target, exhibiting dynamic expression changes in plasma extracellular vesicles (EVs) from MI patients before and after percutaneous coronary intervention (PCI).

To facilitate targeted delivery, we developed an engineered milk-derived EV-like vehicle (mELV) system in which endogenous RNAs were depleted via sonication to reduce off-target effects and improve cargo uniformity.

Echo Biotech 角色

经皮冠状动脉介入治疗PCI前后血浆EV miRNA测序分析

关联平台: Exoomics®

关联服务与能力: EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Cargo-defined engineered vesicles enable targeted miRNA delivery for cardiac repair after myocardial infarction Biomaterials. 2026. DOI: 10.1016/j.biomaterials.2026.124251. PMID/PMCID: 42085858.