颈动脉斑块组织衍生EVs介导动脉粥样硬化并与斑块易损性相关

核心信息

  • 论文英文标题: Carotid Plaque-Derived Small Extracellular Vesicles Mediate Atherosclerosis and Correlate With Plaque Vulnerability
  • 期刊: MedComm
  • 发表年份: 2025
  • DOI: 10.1002/mco2.70220
  • PMID/PMCID: 40391195; PMC12086378

研究概览

Carotid plaque-derived small extracellular vesicles (psEVs) offer insights into tissue- and disease-specific pathobiology, but their roles in plaque vulnerability and their diagnostic potential remain unclear. These findings highlight the roles of psEVs in atherogenesis and plaque vulnerability, providing valuable insights for risk stratification and therapeutic decision-making in aCAS patients.

核心发现

Carotid plaque-derived small extracellular vesicles (psEVs) offer insights into tissue- and disease-specific pathobiology, but their roles in plaque vulnerability and their diagnostic potential remain unclear.

Herein, we isolated psEVs from stable and vulnerable (intraplaque hemorrhage [IPH] or fibrous cap rupture [FCR]) plaques in patients with asymptomatic carotid artery stenosis (aCAS).

Our findings demonstrated that psEVs alone were sufficient to induce inflammatory endothelial dysfunction in vitro and exacerbate atherogenesis in ApoE-deficient mice.

MicroRNA sequencing of psEVs (sequencing cohort, n = 18) identified 21 differentially expressed microRNAs (DEmiRNAs) distinguishing stable and vulnerable plaques, and 41 DEmiRNAs differentiating IPH from FCR subtypes.

Echo Biotech 角色

斑块组织大小囊泡分离鉴定&组织外泌体miRNA测序分析&血浆外泌体qPCR验证

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, qPCR Validation, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Carotid Plaque-Derived Small Extracellular Vesicles Mediate Atherosclerosis and Correlate With Plaque Vulnerability MedComm (2020). 2025. DOI: 10.1002/mco2.70220. PMID/PMCID: 40391195; PMC12086378.