脑脊液CSF外泌体miRNA作为非小细胞肺癌软脑膜转移患者诊断或监测进展的生物标志物
核心信息
- 论文英文标题: Cerebrospinal fluid exosomal microRNAs as biomarkers for diagnosing or monitoring the progression of non-small cell lung cancer with leptomeningeal metastases
- 期刊: BIOTECHNOL GENET ENG
- 发表年份: 2023
- DOI: 10.1016/j.esmoop.2025.106052
- PMID/PMCID: 41564819; PMC12857322
研究概览
This study assessed the association of corticosteroid dose and second-line immunosuppressants for irAEs with survival outcomes in patients with stage IV NSCLC treated with ICIs. Recent studies have demonstrated that high-dose corticosteroids and second-line immunosuppressants may impair survival of patients with immune-related adverse events (irAEs) upon treatment with immune checkpoint inhibitors (ICIs).
核心发现
1%) received second-line immunosuppressants.
The cumulative corticosteroid dose and use of second-line immunosuppressants were not associated with survival.
研究设计
Patients with stage IV NSCLC treated with ICI-based regimens between 2015 and 2022 in the first or second line who received systemic immunosuppressants for irAEs were retrospectively included from 17 hospitals in eight countries worldwide.
Associations of corticosteroid peak and cumulative dose, and use of second-line immunosuppressants with overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) were assessed using Cox proportional hazards regression.
Echo Biotech 角色
CSF外泌体分离鉴定及miRNA测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Cerebrospinal fluid exosomal microRNAs as biomarkers for diagnosing or monitoring the progression of non-small cell lung cancer with leptomeningeal metastases Biotechnology and Genetic Engineering Reviews. 2023. DOI: 10.1016/j.esmoop.2025.106052. PMID/PMCID: 41564819; PMC12857322.