HBV相关肝癌进展过程中EV衍生lncRNAs的特征
核心信息
- 论文英文标题: Characteristics of extracellular vesicle-derived lncRNAs during the progression of HBV-related hepatocellular carcinoma
- 期刊: BMC Cancer
- 发表年份: 2025
- DOI: 10.1186/s12885-025-15237-y
- PMID/PMCID: 41239305; PMC12619285
研究概览
This study characterized EV-derived long non-coding RNAs (lncRNAs) across various stages of liver disease and explored their mechanistic roles. The identified HCC-specific lncRNA biomarkers and regulatory network provide theoretical support for developing novel non-invasive liquid biopsy approaches, holding significant promise for early diagnosis and clinical management of HCC.
核心发现
Liver diseases, including hepatitis B virus (HBV) infection, cirrhosis, and hepatocellular carcinoma (HCC), represent significant global health challenges with limited non-invasive biomarkers for early detection.
Extracellular vesicles (EVs), enriched with disease-specific RNAs, offer a promising avenue for biomarker discovery.
This study characterized EV-derived long non-coding RNAs (lncRNAs) across various stages of liver disease and explored their mechanistic roles.
Serum EVs were isolated from 24 participants (5 healthy controls, 5 chronic hepatitis B patients, 5 liver cirrhosis patients, 4 hepatocellular adenoma patients, and 5 HCC patients) using ultracentrifugation and validated by transmission electron microscopy, nanoparticle tracking analysis, and Western blot.
Echo Biotech 角色
血清外泌体长链RNA测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV lncRNA/mRNA Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Characteristics of extracellular vesicle-derived lncRNAs during the progression of HBV-related hepatocellular carcinoma BMC cancer. 2025. DOI: 10.1186/s12885-025-15237-y. PMID/PMCID: 41239305; PMC12619285.