日本血吸虫感染小鼠血浆细外泌体的的MicroRNA图谱
核心信息
- 论文英文标题: Characterization of MicroRNA Cargo of Extracellular Vesicles Isolated From the Plasma of Schistosoma japonicum-Infected Mice
- 期刊: FRONT CELL INFECT MI
- 发表年份: 2022
- DOI: 10.3389/fcimb.2022.803242
- PMID/PMCID: 35295754; PMC8918519
研究概览
Herein, we investigated the microRNA (miRNA) profiles of EVs isolated from host plasma at different stages of Schistosoma japonicum infection (lung stage: 3 days post-infection (dpi), and liver stages: 14 and 21 dpi) to identify miRNA cargo potentially involved in the pathogenesis and immune regulation of schistosomiasis. japonicum infection may also provide valuable clues for identifying novel biomarkers for schistosomiasis diagnosis.
核心发现
Schistosoma is a genus of parasitic trematodes that undergoes complex migration in final hosts, finally developing into adult worms, which are responsible for egg production and disease dissemination.
Recent studies documented the importance of extracellular vesicles (EVs) in the regulation of host-parasite interactions.
Herein, we investigated the microRNA (miRNA) profiles of EVs isolated from host plasma at different stages of Schistosoma japonicum infection (lung stage: 3 days post-infection (dpi), and liver stages: 14 and 21 dpi) to identify miRNA cargo potentially involved in the pathogenesis and immune regulation of schistosomiasis.
Characterization of the isolated plasma EVs revealed their diameter to be approximately 100 nm, containing typical EV markers such as Hsp70 and Tsg101.
Echo Biotech 角色
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Characterization of MicroRNA Cargo of Extracellular Vesicles Isolated From the Plasma of Schistosoma japonicum-Infected Mice FRONT CELL INFECT MI. 2022. DOI: 10.3389/fcimb.2022.803242. PMID/PMCID: 35295754; PMC8918519.