Circ-CREBBP吸附miR-10384和miR-143-3p通过PI3K-Akt信号通路抑制精子凋亡

核心信息

• 论文英文标题: Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p
• 期刊: Commun Biol
• 发表年份: 2022
• DOI: 10.1038/s42003-022-04263-2
• PMID/PMCID: 36476986; PMC9729231

研究概览

Here, we identified 222 differentially expressed circRNAs in SPEVs between boars with high or low sperm motility. Our results suggest that circ-CREBBP may be a promising biomarker and therapeutic target for male reproductive diseases.

核心发现

Male reproductive diseases are becoming increasingly prominent, and sperm quality is an important indicator to reflect these diseases.

Seminal plasma extracellular vesicles (SPEVs) are involved in sperm motility.

However, their effects on sperm remain unclear.

Here, we identified 222 differentially expressed circRNAs in SPEVs between boars with high or low sperm motility.

Echo Biotech 角色

猪精浆外泌体NTA和电镜鉴定及全转录组测序分析

关联平台: Exoomics®

关联服务与能力: EV Basic Characterization (TEM/NTA/WB), EV Whole-Transcriptome Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p Commun Biol. 2022. DOI: 10.1038/s42003-022-04263-2. PMID/PMCID: 36476986; PMC9729231.