hsa_circ_0000563编码的circBTBD7-420aa调控动脉粥样硬化的进展和circBTBD7-420aa工程化外泌体的构建

核心信息

• 论文英文标题: CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes
• 期刊: JACC Basic Transl Sci
• 发表年份: 2025
• DOI: 10.1016/j.jacbts.2024.09.003
• PMID/PMCID: 40131148; PMC11897471

研究概览

We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. This study suggests that circBTBD7-420aa may inhibit the progression of atherosclerosis and serve as a new target for the diagnosis and treatment of coronary artery disease.

核心发现

Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated.

We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563.

Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway.

In addition, we constructed engineered exosomes loaded with circBTBD7-420aa that can target vascular smooth muscle cells by modifying peptide fragments targeting osteopontin.

Echo Biotech 角色

293F外泌体蛋白外载+内载服务(未引用)

关联平台: Echosome®

关联服务与能力: Small RNA / Cargo Loading

关联产品或试剂: 无明确产品引用

参考文献

原始论文: CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes JACC-Basic to translational science. 2025. DOI: 10.1016/j.jacbts.2024.09.003. PMID/PMCID: 40131148; PMC11897471.