循环外泌体 miR-363-5p 通过下调 PDGFB 抑制淋巴结转移，并作为潜在的乳腺癌无创生物标志物
核心信息
- 论文英文标题: Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer
- 期刊: Mol Oncol
- 发表年份: 2021
- DOI: 10.1002/1878-0261.13029
- PMID/PMCID: 34058065; PMC8410538
研究概览
We identified an exosomal miRNA, miR-363-5p, that was significantly downregulated in exosomes from plasma of BC patients with LN metastasis which exhibited a consistent decreasing trend in tissue samples from multiple independent datasets. Our study revealed, for the first time, plasma exosomal miR-363-5p plays a tumor suppressor role in BC and has the potential for noninvasive LN staging and prognosis prediction of BC.
核心发现
Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN-negative breast cancer (BC) patients but it is prone to false-negative results and complications.
Thus, an accurate noninvasive approach for LN staging is urgently needed in clinical practice.
Here, circulating exosomal microRNA (miRNA) expression profiles in peripheral blood from BC patients and age-matched healthy women were obtained and analyzed.
We identified an exosomal miRNA, miR-363-5p, that was significantly downregulated in exosomes from plasma of BC patients with LN metastasis which exhibited a consistent decreasing trend in tissue samples from multiple independent datasets.
Echo Biotech 角色
血浆外泌体miRNA测序分析
关联平台: Exoomics®
关联服务与能力: EV miRNA Profiling / Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer Mol Oncol. 2021. DOI: 10.1002/1878-0261.13029. PMID/PMCID: 34058065; PMC8410538.