血浆外泌体miR-122-5p预测术后房颤新型生物标志物

核心信息

• 论文英文标题: Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation
• 期刊: J CARDIOVASC TRANSL
• 发表年份: 2022
• DOI: 10.1007/s12265-022-10267-4
• PMID/PMCID: 35513595

研究概览

Our study aimed to identify the difference in exosomal miRNA and further explore its role in the diagnosis of POAF. Our study revealed that exosomal miRNAs exert enormous potential in evaluating the severity or prognostic of POAF.

核心发现

Postoperative atrial fibrillation (POAF) is a frequent complication associated with increased periprocedural mortality and morbidity after cardiac surgery.

Our study aimed to identify the difference in exosomal miRNA and further explore its role in the diagnosis of POAF.

First, the differentially expressed miRNAs (DEMs) were obtained by high-throughput RNA sequencing.

Second, the DEMs target genes were put into gene ontology (GO) and KEGG pathway analysis.

Echo Biotech 角色

Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation Journal of Cardiovascular Translational Research. 2022. DOI: 10.1007/s12265-022-10267-4. PMID/PMCID: 35513595.