血浆sEV循环miRNA 作为小儿癫痫和耐药性癫痫的潜在诊断生物标志物
核心信息
- 论文英文标题: Circulating MicroRNAs From Plasma Small Extracellular Vesicles as Potential Diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy
- 期刊: Front Mol Neurosci
- 发表年份: 2022
- DOI: 10.3389/fnmol.2022.823802
- PMID/PMCID: 35221916; PMC8866954
研究概览
In the present study, we aimed to identify plasma small extracellular vesicles (sEVs) derived microRNAs (miRNAs) from the plasma samples of children for predicting the prognosis in patients with epilepsy and drug-resistant epilepsy. We identified and confirmed plasma sEVs derived miRNA biomarkers that could be considered as potential therapeutic targets for pediatric epilepsy and drug-resistant epilepsy.
核心发现
Pediatric epilepsy is a neurological condition that causes repeated and unprovoked seizures and is more common in 1-5-year-old children.
Drug resistance has been indicated as a key challenge in improving the clinical outcomes of patients with pediatric epilepsy.
In the present study, we aimed to identify plasma small extracellular vesicles (sEVs) derived microRNAs (miRNAs) from the plasma samples of children for predicting the prognosis in patients with epilepsy and drug-resistant epilepsy.
A total of 90 children clinically diagnosed with epilepsy [46 antiepileptic drug (AED)-responsive epilepsy and 44 drug-resistant epilepsy] and 37 healthy controls (HCs) were enrolled in this study.
Echo Biotech 角色
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Circulating MicroRNAs From Plasma Small Extracellular Vesicles as Potential Diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy Front Mol Neurosci. 2022. DOI: 10.3389/fnmol.2022.823802. PMID/PMCID: 35221916; PMC8866954.