从临床外泌体分析到工程治疗：富含miR-21-5p的外泌体通过YAP1途径逆转薄子宫内膜

核心信息

• 论文英文标题: From clinical exosome analysis to engineered therapy: miR-21-5p-Enriched exosomes reverse thin endometrium via the YAP1 pathway
• 期刊: Biomaterials
• 发表年份: 2026
• DOI: 10.1016/j.biomaterials.2026.124271
• PMID/PMCID: 42119168

研究概览

Thin endometrium (TE) is associated with reduced pregnancy rates and adverse obstetric outcomes. This work identifies novel diagnostic biomarkers and pioneered an innovative therapeutic approach, thereby offering a potential strategy for improving the clinical management of TE.

核心发现

Thin endometrium (TE) is associated with reduced pregnancy rates and adverse obstetric outcomes.

While current interventions including hysteroscopic adhesiolysis and hormonal regimens offer partial solutions, functional restoration remains challenging due to the elusive pathogenesis of TE.

5%) in TE-derived UF-Exo that critically underpins disease progression.

Leveraging these insights, a miRNA-reprogramming therapeutics is established based on engineered human umbilical cord mesenchymal stem cell-derived exosome (hUCMSCs-Exo) that precisely orchestrates endometrial cellular proliferation and angiogenic processes.

Echo Biotech 角色

HuMSC EV 用Exoload负载miRNA mimics（该研究结合水凝胶）

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Small RNA / Cargo Loading, Research Reagent / Product Supply

关联产品或试剂: ExoLoad® Nucleic Acid Loading Kit

参考文献

原始论文: From clinical exosome analysis to engineered therapy: miR-21-5p-Enriched exosomes reverse thin endometrium via the YAP1 pathway Biomaterials. 2026. DOI: 10.1016/j.biomaterials.2026.124271. PMID/PMCID: 42119168.