艰难梭菌衍生EVs诱导巨噬细胞的促炎反应
核心信息
- 论文英文标题: Clostridioides difficile-Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages
- 期刊: J Extracell Vesicles
- 发表年份: 2026
- DOI: 10.1002/jev2.70251
- PMID/PMCID: 41904635; PMC13140506
研究概览
This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630-EVs), which released spherical EVs during in vitro culture, in modulating pro-inflammatory cytokine production in macrophages. These findings suggest that FliC may play a critical role in intestinal mucosal injury during CDI, highlighting its potential as a therapeutic target for mitigating inflammation in CDI.
核心发现
Clostridioides difficile (CD) is a leading cause of antibiotic-associated diarrhoea in both hospitalized and non-hospitalized patients.
This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630-EVs), which released spherical EVs during in vitro culture, in modulating pro-inflammatory cytokine production in macrophages.
Proteomic analysis identified a total of 1064 proteins within CD630-EVs, including four immune-related proteins: FliC, TrxA, TrxA2 and HtpG.
Notably, FliC exhibited the highest expression intensity within immune-related pathways.
Echo Biotech 角色
Exosupur排阻柱分离艰难梭菌CD630菌株EVs（应该是ES911分离细菌菌液EV）
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Clostridioides difficile-Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages Journal of extracellular vesicles. 2026. DOI: 10.1002/jev2.70251. PMID/PMCID: 41904635; PMC13140506.