HEK293F衍生EVs作为有前景的药物递送载体的稳定性和安全性综合评价
核心信息
- 论文英文标题: A comprehensive evaluation of stability and safety for HEK293F-derived extracellular vesicles as promising drug delivery vehicles
- 期刊: J Control Release
- 发表年份: 2025
- DOI: 10.1016/j.jconrel.2025.113673
- PMID/PMCID: 40169120
研究概览
Our study demonstrates that HEK293F-EVs maintain stable physicochemical characteristics and compositions across batches and possess a superior safety profile, suggesting their significant potential as a safe and reliable drug delivery platform for clinical applications. A comprehensive understanding of their batch stability and in vivo safety is prerequisite for clinical translation.
核心发现
HEK293F-derived extracellular vesicles (HEK293F-EVs) have great potential as next-generation drug delivery vehicles.
A comprehensive understanding of their batch stability and in vivo safety is prerequisite for clinical translation.
HEK293F-EVs were purified using ultracentrifugation combined with size exclusion chromatography, and their physicochemical properties, such as morphology, size distribution, and biomarkers, were thoroughly characterized.
Raman spectroscopy and multi-omics analyses were employed to elaborate their molecular composition.
Echo Biotech 角色
Exosupur细胞上清排阻柱ES914/ES933+细胞上清外泌体多组学(miRNA+蛋白质组)
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, EV Re-purification / Free-Dye Removal, EV Proteomics, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: A comprehensive evaluation of stability and safety for HEK293F-derived extracellular vesicles as promising drug delivery vehicles Journal of controlled release. 2025. DOI: 10.1016/j.jconrel.2025.113673. PMID/PMCID: 40169120.