脐带血自然杀伤细胞外泌体通过ITGB2-穿孔素介导的包膜破坏在体外和体内抑制寨卡病毒的感染性

核心信息

• 论文英文标题: Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo
• 期刊: Bioact Mater
• 发表年份: 2026
• DOI: 10.1016/j.bioactmat.2026.01.030
• PMID/PMCID: 41674556; PMC12887259

研究概览

Zika virus (ZIKV) can traverse the placental barrier, leading to fetal microcephaly and congenital zika syndrome (CZS). The viral E protein mediates host-cell interactions and infection.

核心发现

Zika virus (ZIKV) can traverse the placental barrier, leading to fetal microcephaly and congenital zika syndrome (CZS).

The viral E protein mediates host-cell interactions and infection.

Here, we demonstrated that cord blood natural killer cell-derived extracellular vesicles (CBNK-EVs) potently inhibit ZIKV infection in vitro without compromising cellular viability.

Mechanistically, CBNK-EVs engage ZIKV through ITGB2, a surface-enriched integrin that interacts with the viral E protein, facilitating nanoparticle-virion contact or membrane fusion.

Echo Biotech 角色

Exosupur袖珍柱ES9016去除游离染料

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Re-purification / Free-Dye Removal, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo Bioactive materials. 2026. DOI: 10.1016/j.bioactmat.2026.01.030. PMID/PMCID: 41674556; PMC12887259.