去泛素酶USP35通过调节代谢重编程促进胃癌腹膜扩散
核心信息
- 论文英文标题: De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming
- 期刊: Cell Death Dis
- 发表年份: 2025
- DOI: 10.1038/s41419-025-08322-4
- PMID/PMCID: 41372134; PMC12706015
研究概览
The aim of this study was to identify the mechanism by which USP35 promotes the formation of the pre-peritoneal-metastasis adaptive microenvironment of GC and to find potential therapeutic targets. USP35 expression is the highest in MKN-45P, which is closely related to its high peritoneal metastasis potential.
核心发现
The enhanced adhesion between gastric cancer (GC) cells and peritoneal mesothelial cells (PMCs) is one of the key factors in the formation of the pre-peritoneal-metastasis adaptive microenvironment.
USP35 belongs to the ubiquitin-specific protease family and is involved in regulating the occurrence and progression of various diseases.
However, whether this gene can regulate the adhesion of GC cells to PMCs has not been clarified.
The aim of this study was to identify the mechanism by which USP35 promotes the formation of the pre-peritoneal-metastasis adaptive microenvironment of GC and to find potential therapeutic targets.
Echo Biotech 角色
细胞系外泌体分离表征&蛋白质组
关联平台: Exoomics®
关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Proteomics
关联产品或试剂: 无明确产品引用
参考文献
原始论文: De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming Cell death & disease. 2025. DOI: 10.1038/s41419-025-08322-4. PMID/PMCID: 41372134; PMC12706015.