1型糖尿病患者血浆外泌体circRNA的差异表达及生信分析-未qPCR验证

核心信息

• 论文英文标题: Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus
• 期刊: J Immunol Res
• 发表年份: 2022
• DOI: 10.1155/2022/3625052
• PMID/PMCID: 36339941; PMC9634467

研究概览

Here, we identified the exosomal circRNA expression profiles in the plasma of T1DM patients and explored their potential function using bioinformatics analysis. Multiple bioinformatics analysis was applied to investigate the potential biological functions of exosomal circRNAs.

核心发现

A total of 784 differentially expressed exosomal circRNAs have been identified in T1DM patients, of which 528 were upregulated and 256 were downregulated.

Gene Ontology analysis enriched terms such as protein ubiquitination involved in ubiquitin-dependent protein catabolic protein (GO:0042787), membrane (GO:0016020), and GTPase activator activity (GO:0005096).

The most enriched pathway in Kyoto Encyclopedia of Genes and Genomes was ubiquitin-mediated proteolysis (ko04120).

The miRNA-targeting prediction method was used to identify the miRNAs that bind to circRNAs, and circRNA-miRNA-mRNA pathways were constructed, indicating that interactions between circRNA, miRNA, and gene might be involved in the disease progression.

Echo Biotech 角色

与EA43、EA56同一个长链数据拆分发表

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV lncRNA/mRNA Sequencing, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus J Immunol Res. 2022. DOI: 10.1155/2022/3625052. PMID/PMCID: 36339941; PMC9634467.