血浆外泌体蛋白作为慢性乙型肝炎相关肝病诊断生物标志物
核心信息
- 论文英文标题: Differential proteomic analysis of plasma-derived exosomes as diagnostic biomarkers for chronic HBV-related liver disease
- 期刊: SCI REP-UK
- 发表年份: 2022
- DOI: 10.1038/s41598-022-13272-4
- PMID/PMCID: 36002595; PMC9402575
研究概览
Hepatitis B virus (HBV) infection is still a major public health problem worldwide. Thus, serum exosomes may be used as novel, liquid biopsy biomarkers to provide useful clinical information for the diagnosis of HBV-related liver diseases at different stages.
核心发现
Hepatitis B virus (HBV) infection is still a major public health problem worldwide.
We aimed to identify new, non-invasive biomarkers for the early diagnosis of chronic HBV-related diseases, reveal alterations in the progression of chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).
Here, exosomes were isolated and characterized through size exclusion chromatography and nanoparticle tracking analysis.
Profiles of differentially expressed proteins (DEPs) were analyzed through liquid chromatography-tandem mass spectrometry (LC-MS/MS), Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses.
Echo Biotech 角色
血浆外泌体蛋白质组未验证
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV Proteomics, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Differential proteomic analysis of plasma-derived exosomes as diagnostic biomarkers for chronic HBV-related liver disease Scientific reports. 2022. DOI: 10.1038/s41598-022-13272-4. PMID/PMCID: 36002595; PMC9402575.