发现并验证一种用于诊断肾移植后纤维化的尿液细胞外囊泡蛋白标志物

核心信息

• 论文英文标题: Discovery and validation of a urinary extracellular vesicleprotein signature for the diagnosis of renal allograftfibrosis
• 期刊: Interdisciplinary Medicine
• 发表年份: 2026
• DOI: 10.1002/inmd.70108

研究概览

Our study is the first to report the suEV protein biomarkers for the diagnosis of allograft fibrosis, offering a non‐invasive alternative to renal biopsy and enabling improved risk stratification for transplant patients, which aids in better management of transplant recipients to improve long‐term allograft survival. Through unbiased proteomic and in‐depth bioinformatic analyses, we delineated an extensive protein landscape of suEVs and identified sorting nexin 3 (SNX3), vacuolar protein sorting‐associated protein 4B (VPS4B) and smoothened (SMO) proteins as potential biomarkers for accurate and consistent diagnosis of fibrosis.

Echo Biotech 角色

NanoFCM检测

关联平台: Exoomics®

关联服务与能力: EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Discovery and validation of a urinary extracellular vesicleprotein signature for the diagnosis of renal allograftfibrosis Interdisciplinary Medicine. 2026. DOI: 10.1002/inmd.70108.