细胞外基质ECM硬度影响货物分拣到MSC EV中以调节其分泌和吸收行为

核心信息

  • 论文英文标题: ECM stiffness affects cargo sorting into MSC-EVs to regulate their secretion and uptake behaviors
  • 期刊: J NANOBIOTECHNOL
  • 发表年份: 2024
  • DOI: 10.1186/s12951-024-02411-w
  • PMID/PMCID: 38515095; PMC10956366

研究概览

Using multi-omics analysis, we found that a decrease in ECM stiffness impeded the sorting of vesicular transport-related proteins and autophagy-related lipids into MSC-EVs, impairing their secretion and subsequent uptake by macrophages. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have garnered extensive attention as natural product-based nanomedicines and potential drug delivery vehicles.

核心发现

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have garnered extensive attention as natural product-based nanomedicines and potential drug delivery vehicles.

However, the specific mechanism for regulating MSC-EVs secretion and delivery remains unclear.

Here, we demonstrate that extracellular matrix (ECM) stiffness regulates the secretion and delivery of EVs by affecting MSCs' cargo sorting mechanically.

Using multi-omics analysis, we found that a decrease in ECM stiffness impeded the sorting of vesicular transport-related proteins and autophagy-related lipids into MSC-EVs, impairing their secretion and subsequent uptake by macrophages.

Echo Biotech 角色

MSC外泌体miRNA测序分析

关联平台: Exoomics®

关联服务与能力: EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: ECM stiffness affects cargo sorting into MSC-EVs to regulate their secretion and uptake behaviors Journal of nanobiotechnology. 2024. DOI: 10.1186/s12951-024-02411-w. PMID/PMCID: 38515095; PMC10956366.