针对内皮细胞靶向修饰的人参外泌体递送IL-6 SiRNA改善肝脏缺血再灌注损伤(植物EV负载小核酸+VHP靶向肽)
核心信息
- 论文英文标题: Endothelial-targeted modification of ginseng-derived exosomes for IL-6 SiRNA delivery ameliorates hepatic ischemia-reperfusion injury
- 期刊: J Nanobiotechnology
- 发表年份: 2026
- DOI: 10.1186/s12951-025-03954-2
- PMID/PMCID: 41491215; PMC12781530
研究概览
This study developed endothelial-targeting VHPKQHR peptide (VHP)-modified ginseng-derived exosomes (G-Exos) loaded with IL-6 small interfering RNA (Si-IL6) (siRNA@VG-Exos) to mitigate liver IRI. Furthermore, they promoted the restoration of mitochondrial membrane potential, maintaining mitochondrial homeostasis.
核心发现
Liver ischemia-reperfusion injury (IRI) serves as a critical pathological basis for post-hepatectomy liver failure and graft dysfunction following liver transplantation.
Excessive inflammatory responses, oxidative stress, and cell death are key mechanisms underlying IRI.
The lack of multi-targeted therapies contributes to the current insufficiency in clinical IRI management.
This study developed endothelial-targeting VHPKQHR peptide (VHP)-modified ginseng-derived exosomes (G-Exos) loaded with IL-6 small interfering RNA (Si-IL6) (siRNA@VG-Exos) to mitigate liver IRI.
Echo Biotech 角色
ExoBrooch VHP靶向肽脂锚试剂盒
关联平台: Echosome®, Research Reagents & Tools
关联服务与能力: Targeting Peptide / Surface Modification, Research Reagent / Product Supply
关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit
参考文献
原始论文: Endothelial-targeted modification of ginseng-derived exosomes for IL-6 SiRNA delivery ameliorates hepatic ischemia-reperfusion injury Journal of nanobiotechnology. 2026. DOI: 10.1186/s12951-025-03954-2. PMID/PMCID: 41491215; PMC12781530.