内皮衍生的工程化EVs在急性肺损伤中保护肺内皮屏障

核心信息

• 论文英文标题: Endothelium-Derived Engineered Extracellular Vesicles Protect the Pulmonary Endothelial Barrier in Acute Lung Injury
• 期刊: Adv Sci
• 发表年份: 2023
• DOI: 10.1002/advs.202306156
• PMID/PMCID: 38062916; PMC10853733

研究概览

Acute lung injury (ALI) is a severe respiratory disease with a high mortality rate. Taken together, these findings suggest that LET-EVs-miRNA-125b can treat ALI by protecting the endothelial barrier integrity.

核心发现

Acute lung injury (ALI) is a severe respiratory disease with a high mortality rate.

The integrity of the pulmonary endothelial barrier influences the development and prognosis of ALI.

Therefore, it has become an important target for ALI treatment.

Extracellular vesicles (EVs) are promising nanotherapeutic agents against ALI.

Echo Biotech 角色

lamp2b-肺微血管内皮细胞靶向肽融合质粒构建慢病毒包装

关联平台: Echosome®

关联服务与能力: Targeting Peptide / Surface Modification

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Endothelium-Derived Engineered Extracellular Vesicles Protect the Pulmonary Endothelial Barrier in Acute Lung Injury Advanced Science. 2023. DOI: 10.1002/advs.202306156. PMID/PMCID: 38062916; PMC10853733.