工程化人胎盘MSC EVs通过抑制Nat10介导的血管平滑肌细胞衰老以减弱腹主动脉瘤的形成

核心信息

• 论文英文标题: Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence
• 期刊: Biomaterials
• 发表年份: 2026
• DOI: 10.1016/j.biomaterials.2026.124109
• PMID/PMCID: 41791327

研究概览

Human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) have demonstrated anti-senescence effects across various diseases. However, their role in abdominal aortic aneurysm (AAA), a degenerative aortic pathology, remains unexplored.

核心发现

Human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) have demonstrated anti-senescence effects across various diseases.

However, their role in abdominal aortic aneurysm (AAA), a degenerative aortic pathology, remains unexplored.

Our findings demonstrated that hPMSC-EVs effectively delay vascular smooth muscle cell (VSMC) senescence.

In vivo, modification of hPMSC-EVs with an osteopontin(OPN)-targeted peptide facilitated precise homing to aneurysmal sites and improved local retention.

Echo Biotech 角色

ExoBrooch OPN-TP靶向肽脂锚定制--以靶向OPN高表达的平滑肌细胞

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Targeting Peptide / Surface Modification, Custom Ligand / Peptide-Lipid Synthesis, Research Reagent / Product Supply

关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

参考文献

原始论文: Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence Biomaterials. 2026. DOI: 10.1016/j.biomaterials.2026.124109. PMID/PMCID: 41791327.