hTERT驱动的永生化脐带间充质干细胞系的建立及其在肝衰竭小鼠中的应用

核心信息

• 论文英文标题: Establishing an hTERT-driven immortalized umbilical cord-derived mesenchymal stem cell line and its therapeutic application in mice with liver failure
• 期刊: J Tissue Eng
• 发表年份: 2023
• DOI: 10.1177/20417314231200328
• PMID/PMCID: 37736245; PMC10510347

研究概览

Acute liver failure (ALF) is characterized by rapid liver cell destruction. Inoculation of hTERT-UCMSC and its exosomes could potentially be used in clinics for the treatment of liver failure in the future.

核心发现

Acute liver failure (ALF) is characterized by rapid liver cell destruction.

It is a multi-etiological and fulminant complication with a clinical mortality of over 80%.

Therapy using mesenchymal stem cells (MSCs) or MSCs-derived exosomes can alleviate acute liver injury, which has been demonstrated in animal experiments and clinical application.

However, similar to other stem cells, different cell sources, poor stability, cell senescence and other factors limit the clinical application of MSCs.

Echo Biotech 角色

MSC外泌体分离

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Establishing an hTERT-driven immortalized umbilical cord-derived mesenchymal stem cell line and its therapeutic application in mice with liver failure J Tissue Eng. 2023. DOI: 10.1177/20417314231200328. PMID/PMCID: 37736245; PMC10510347.