结直肠癌外泌体整合素αvβ3通过诱导癌症相关成纤维细胞CAF活化促进肝脏转移前生态位的形成
核心信息
- 论文英文标题: Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation
- 期刊: Clin Exp Med
- 发表年份: 2026
- DOI: 10.1007/s10238-026-02193-5
- PMID/PMCID: 42223705; 3496330
研究概览
In this study, we found that integrin αvβ3 is associated with CRLM and the poor clinical prognosis. Hepatic stellate cells (HSCs) can promote CRLM by forming cancer-associated fibroblasts (CAFs), but the mechanism remains unclear.
核心发现
The formation of the liver pre-metastatic niche (PMN) is a critical factor in the development of colorectal cancer liver metastasis (CRLM), so understanding the mechanism of the liver PMN is crucial for the prevention and treatment of CRLM.
Hepatic stellate cells (HSCs) can promote CRLM by forming cancer-associated fibroblasts (CAFs), but the mechanism remains unclear.
In this study, we found that integrin αvβ3 is associated with CRLM and the poor clinical prognosis.
Exosomal integrin αvβ3 derived from CRC can target HSCs via fibronectin to mediate their activation.
Echo Biotech 角色
Exosupur排阻柱ES910
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Cell-Culture Supernatant EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation Clinical and experimental medicine. 2026. DOI: 10.1007/s10238-026-02193-5. PMID/PMCID: 42223705; 3496330.