外泌体PD-L1和N-钙粘蛋白预测骨肉瘤患者的肺转移进展

核心信息

• 论文英文标题: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients
• 期刊: J Nanobiotechnol
• 发表年份: 2020
• DOI: 10.1186/s12951-020-00710-6
• PMID/PMCID: 33092576; PMC7579953

研究概览

We examined serum exosomes from 70 OS patients, 9 patients with benign tumors and 22 healthy donors. Detection of exosomal PD-L1 and N-cadherin from serum of OS patients may predict pulmonary metastasis progression for OS patients.

核心发现

The characteristics of exosomes derived from OS patient serum and OS cell lines were confirmed by several methods.

We found OS patients had a higher level of exosomal PD-L1 compared to healthy donors.

Meanwhile, OS patients with pulmonary metastasis also showed a relatively higher level of exosomal PD-L1 than patients without metastasis.

Next, bioinformatic analysis demonstrated that Sr-exosomes isolated from OS patients may involve in the important process of immune function and cancer pathogenesis for OS patients.

Echo Biotech 角色

外泌体长链RNA测序

关联平台: Exoomics®

关联服务与能力: EV lncRNA/mRNA Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients J Nanobiotechnol. 2020. DOI: 10.1186/s12951-020-00710-6. PMID/PMCID: 33092576; PMC7579953.