多发性骨髓瘤患者血清中外泌体miRNA表达谱及预后评估
核心信息
- 论文英文标题: Exosome miRNAs profiling in serum and prognostic evaluation in patients with multiple myeloma
- 期刊: BLOOD SCI
- 发表年份: 2023
- DOI: 10.1097/BS9.0000000000000160
- PMID/PMCID: 37546707; PMC10400059
研究概览
Our study aimed at identifying the expression profile of exosomal miRNAs (exo-miRNAs) in the serum of multiple myeloma (MM) patients and investigating the regulation networks and their potential functions by integrated bioinformatics analysis. 13 core exo-miRNA target genes were applied to create a novel prognostic signature to provide risk stratification for MM patients, which is associated with the immune microenvironment of MM patients.
核心发现
MicroRNAs (MiRNAs) carried by exosomes play pivotal roles in the crosstalk between cell components in the tumor microenvironment.
Our study aimed at identifying the expression profile of exosomal miRNAs (exo-miRNAs) in the serum of multiple myeloma (MM) patients and investigating the regulation networks and their potential functions by integrated bioinformatics analysis.
Exosomes in serum from 19 newly diagnosed MM patients and 9 healthy donors were isolated and the miRNA profile was investigated by small RNA sequencing.
Differential expression of exo-miRNAs was calculated and target genes of miRNAs were predicted.
Echo Biotech 角色
血清外泌体分离鉴定及miRNA测序分析（文章中测序公司写错了）
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Exosome miRNAs profiling in serum and prognostic evaluation in patients with multiple myeloma Blood science. 2023. DOI: 10.1097/BS9.0000000000000160. PMID/PMCID: 37546707; PMC10400059.