口腔鳞状细胞癌组织外泌体促进糖尿病伤口愈合
核心信息
- 论文英文标题: Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing
- 期刊: AM J PHYSIOL-CELL PH
- 发表年份: 2023
- DOI: 10.1152/ajpcell.00541.2022
- PMID/PMCID: 37154491
研究概览
In this study, we extracted Ti-Exos from human oral squamous carcinoma and paracancerous tissue by ultracentrifugation, size exclusion chromatography, and ultrafiltration and performed exosome characterization. In vivo assays also verified that OSCC Ti-Exos could promote diabetic wound healing, demonstrated preliminary biosafety in mice, and have promise as therapeutic applications.
核心发现
It is a widespread and difficult problem that refractory diabetic wounds have a poor local environment and prolonged inflammatory irritation.
Tumor cell-derived exosomes play an important role in the development of tumors, as they can promote tumor cell proliferation, migration, and invasion and enhance tumor cell activity.
However, tumor tissue-derived exosomes (Ti-Exos) have been less studied, and it is unclear how they affect wound healing.
In this study, we extracted Ti-Exos from human oral squamous carcinoma and paracancerous tissue by ultracentrifugation, size exclusion chromatography, and ultrafiltration and performed exosome characterization.
Echo Biotech 角色
组织外泌体分离鉴定
关联平台: Exoomics®
关联服务与能力: Tissue EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB)
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2023. DOI: 10.1152/ajpcell.00541.2022. PMID/PMCID: 37154491.