子宫内膜异位症宫腔液外泌体通过抑制JNK通路介导免疫失调

核心信息

• 论文英文标题: Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis
• 期刊: Biomedicines
• 发表年份: 2022
• DOI: 10.3390/biomedicines10123110
• PMID/PMCID: 36551866; PMC9775046

研究概览

This study mainly investigated the role of exosomes from the uterine cavity in endometriosis. In summary, we propose that exosomes from the uterine cavity in patients with endometriosis may affect the phenotype of macrophages by inhibiting the JNK signaling pathway, thus mediating the formation of an immunological microenvironment conducive to the development of endometriosis.

核心发现

Endometriosis is a chronic inflammatory disease with an uncertain pathogenesis.

Peritoneal immune dysregulation plays an important role in the pathogenesis of endometriosis.

Exosomes are messengers of intercellular communication.

This study mainly investigated the role of exosomes from the uterine cavity in endometriosis.

Echo Biotech 角色

抽吸宫腔积液外泌体分离鉴定 & miRNA测序分析 & qPCR验证

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, qPCR Validation, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis Biomedicines. 2022. DOI: 10.3390/biomedicines10123110. PMID/PMCID: 36551866; PMC9775046.