探索卵泡液外泌体对猪卵丘细胞和卵母细胞功能的影响：基于ENSSSCG 0000042788ssc-Mir-504PDHA1轴的调节网络分析
核心信息
- 论文英文标题: Exploring the impact of follicular fluid exosomes on porcine cumulus cell and oocyte function: Regulatory network analysis based on the ENSSSCG00000042788/ssc-miR-504/PDHA1 axis
- 期刊: Theriogenology
- 发表年份: 2025
- DOI: 10.1016/j.theriogenology.2025.117556
- PMID/PMCID: 40614304
研究概览
In this study, we conducted transcriptomic analysis on cumulus cells cultured with varying exosome concentrations and identified 334 differentially expressed long noncoding RNAs (lncRNAs). Functional enrichment analysis indicated that the differentially expressed lncRNAs may be involved in cumulus cell expansion, oocyte maturation, and embryo development.
核心发现
The development and maturation of mammalian oocytes are crucial stages in reproduction, directly influencing embryo health and the genetic quality of offspring.
Follicular fluid serves as the microenvironment for oocyte development, with exosomes playing a key role in regulating the activities of cumulus cells and oocytes.
However, the mechanisms governing porcine oocyte maturation remain incompletely understood.
In this study, we conducted transcriptomic analysis on cumulus cells cultured with varying exosome concentrations and identified 334 differentially expressed long noncoding RNAs (lncRNAs).
Echo Biotech 角色
卵泡液外泌体分离&猪卵母细胞全转录组测序分析
关联平台: Exoomics®
关联服务与能力: Biofluid EV Isolation & Purification, EV Whole-Transcriptome Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Exploring the impact of follicular fluid exosomes on porcine cumulus cell and oocyte function: Regulatory network analysis based on the ENSSSCG00000042788/ssc-miR-504/PDHA1 axis Theriogenology. 2025. DOI: 10.1016/j.theriogenology.2025.117556. PMID/PMCID: 40614304.