探索卒中后抑郁症：外泌体蛋白质组学揭示潜在的机制和潜在的血浆生物标志物
核心信息
- 论文英文标题: Exploring Post-Stroke Depression: Exosomal Proteomics Reveals Underlying Mechanisms and Potential Plasma Biomarkers
- 期刊: Brain Res Bull
- 发表年份: 2026
- DOI: 10.1016/j.brainresbull.2026.111940
- PMID/PMCID: 42142599
研究概览
This study aims to identify potential biomarkers for PSD through proteomics analysis of plasma exosomes. These results suggest that the complement and coagulation pathways may be involved in the pathophysiological process of post-stroke depression (PSD), in which key proteins such as PLG, HRG, and CPB2 are likely to play important roles.
核心发现
A total of 111 significantly differentially expressed proteins were identified between the two groups, including 44 upregulated and 67 downregulated.
GO and KEGG enrichment analyses revealed that the upregulated proteins were significantly enriched in the complement and coagulation cascades.
Protein-protein interaction network analysis further identified PLG, HRG, and CPB2 as core network nodes.
ROC curve analysis demonstrated favorable predictive efficacy for the combined detection of these three proteins, and their expression levels were positively correlated with HAM-D scores.
研究设计
Patients with acute ischemic stroke were grouped according to the Hamilton Depression Rating Scale (HAMD).
Exosomes were isolated and purified from plasma samples using size exclusion filtration combined with ultracentrifugation.
Differentially expressed proteins (DEPs) were screened and subjected to functional analysis and identification using direct data-independent acquisition (direct-DIA) proteomics and bioinformatics approaches.
Echo Biotech 角色
血浆外泌体分离表征&DIA蛋白质组学
关联平台: Exoomics®
关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Proteomics
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Exploring Post-Stroke Depression: Exosomal Proteomics Reveals Underlying Mechanisms and Potential Plasma Biomarkers Brain Research Bulletin. 2026. DOI: 10.1016/j.brainresbull.2026.111940. PMID/PMCID: 42142599.