细胞外囊泡PD-L1诱导CD4+T细胞功能障碍致脓毒症免疫抑制

核心信息

• 论文英文标题: Extracellular vesicle-associated PD-L1 induces CD4+ T cell dysfunction and contributes to immunosuppression in sepsis
• 期刊: Cell Commun Signal
• 发表年份: 2026
• DOI: 10.1186/s12964-026-02724-3
• PMID/PMCID: 41668092; PMC12990564

研究概览

We evaluated the relationship of EV-associated PD-L1 level to immune function and prognosis in septic patients. EV-associated PD-L1 engaged CD4+ T cells to induce CD4+ T cell dysfunction and may be one of the key mechanisms inducing immunosuppression in sepsis.

核心发现

BACKGROUND: The upregulation of PD-1 on T lymphocytes is one of the key mechanisms driving sepsis-induced immunosuppression.

Nevertheless although it is known that PD-L1 on antigen-presenting cells acts as a ligand for PD-1 on T lymphocytes, it remains to be determined whether extracellular vesicle-associated PD-L1 also serves as its ligand.

METHODS: Plasma extracellular vesicles (EVs) were isolated via ultracentrifugation.

We evaluated the relationship of EV-associated PD-L1 level to immune function and prognosis in septic patients.

Echo Biotech 角色

血浆/细胞上清外泌体电镜表征 & 血浆外泌体NTA & 细胞上清外泌体WB

关联平台: Exoomics®

关联服务与能力: EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Extracellular vesicle-associated PD-L1 induces CD4+ T cell dysfunction and contributes to immunosuppression in sepsis Cell communication and signaling. 2026. DOI: 10.1186/s12964-026-02724-3. PMID/PMCID: 41668092; PMC12990564.