细胞外囊泡衍生miR-144作为慢性间歇性缺氧诱导内皮功能障碍的新机制
核心信息
- 论文英文标题: Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction
- 期刊: Theranostics
- 发表年份: 2022
- DOI: 10.7150/thno.69035
- PMID/PMCID: 35673562; PMC9169375
研究概览
Additionally, we identified that erythrocytes were the primary cellular source of miR-144-enriched serum-derived extracellular vesicles and that erythrocyte-derived extracellular vesicles were largely responsible for chronic intermittent hypoxia-impaired endothelial function. Conclusion: The results expand the scope of blood-borne substances involved in vascular homeostasis and suggest that anti-miR-144-loaded extracellular vesicles may represent a promising therapeutic approach against obstructive sleep apnea or chronic intermittent hypoxia-associated endothelial dysfunction.
核心发现
Rationale: Extracellular vesicles (EVs) play a significant role in cell-cell communication.
However, whether and how extracellular vesicles are involved in chronic intermittent hypoxia-induced endothelial dysfunction is unknown.
Methods: Comparative transcriptomics analysis and miRNA screening were used to identify the possible pathways or target molecules mediating chronic intermittent hypoxia-induced endothelial function.
Serum- or erythrocyte-derived EVs were isolated through ultracentrifugation plus filtration.
Echo Biotech 角色
电镜
关联平台: Exoomics®
关联服务与能力: EV Basic Characterization (TEM/NTA/WB)
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction Theranostics. 2022. DOI: 10.7150/thno.69035. PMID/PMCID: 35673562; PMC9169375.