血浆EVs miRNA作为神经母细胞瘤有前景的诊断和预后生物标志物

核心信息

• 论文英文标题: Extracellular vesicle derived miRNAs from plasma as promising diagnosis and prognosis biomarkers for neuroblastoma
• 期刊: iScience
• 发表年份: 2025
• DOI: 10.1016/j.isci.2025.113636
• PMID/PMCID: 41142119; PMC12549392

研究概览

This study identified plasma sEV-derived miRNA biomarkers for NB diagnosis and MYCN status prediction. Small extracellular vesicles (sEVs) carry microRNAs (miRNAs) with promising diagnostic potential.

核心发现

Neuroblastoma (NB) is the most common extracranial solid tumor in children.

MYCN amplification remains a critical indicator of high-risk disease and poor prognosis.

Small extracellular vesicles (sEVs) carry microRNAs (miRNAs) with promising diagnostic potential.

This study identified plasma sEV-derived miRNA biomarkers for NB diagnosis and MYCN status prediction.

Echo Biotech 角色

血浆外泌体分离鉴定&miRNA测序分析&qPCR验证

关联平台: Exoomics®, Research Reagents & Tools

关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, qPCR Validation, Research Reagent / Product Supply

关联产品或试剂: Exosupur® EV Isolation/Purification Kit

参考文献

原始论文: Extracellular vesicle derived miRNAs from plasma as promising diagnosis and prognosis biomarkers for neuroblastoma iScience. 2025. DOI: 10.1016/j.isci.2025.113636. PMID/PMCID: 41142119; PMC12549392.