内脏脂肪细胞通过EVs介导的miR-155诱导肥胖相关骨骼肌发育异常
核心信息
- 论文英文标题: Extracellular Vesicle-Mediated miR-155 from Visceral Adipocytes Induces Skeletal Muscle Dysplasia in Obesity
- 期刊: cells
- 发表年份: 2025
- DOI: 10.3390/cells14171302
- PMID/PMCID: 40940715; PMC12427855
研究概览
Obesity poses a serious threat to human health, with induced skeletal muscle dysfunction significantly increasing the risk of metabolic syndrome. These findings provide novel mechanistic insights into obesity-induced skeletal muscle dysregulation and facilitate potential therapeutic strategies targeting exosomal miRNA signaling.
核心发现
Obesity poses a serious threat to human health, with induced skeletal muscle dysfunction significantly increasing the risk of metabolic syndrome.
In obesity, it is known that visceral adipose tissue (VAT) mediates the dysregulation of the adipose-muscle axis through exosome-delivered miRNAs, but the associated regulatory mechanisms remain incompletely elucidated.
7 cells/C2C12 cells) to demonstrate that high-fat diet-induced VA-derived extracellular vesicles (HFD VAD-evs) preferentially accumulate in skeletal muscle and induce developmental impairment.
HFD VAD-evs disrupt skeletal muscle homeostasis through dual mechanisms: the direct suppression of myoblast development via exosomal miR-155 cargo and the indirect inhibition of myogenesis through macrophage-mediated inflammatory responses in skeletal muscle.
Echo Biotech 角色
exoload试剂盒负载miRNA inhibitor
关联平台: Echosome®, Research Reagents & Tools
关联服务与能力: Small RNA / Cargo Loading, Research Reagent / Product Supply
关联产品或试剂: ExoLoad® Nucleic Acid Loading Kit
参考文献
原始论文: Extracellular Vesicle-Mediated miR-155 from Visceral Adipocytes Induces Skeletal Muscle Dysplasia in Obesity cells. 2025. DOI: 10.3390/cells14171302. PMID/PMCID: 40940715; PMC12427855.