间歇性低氧暴露的心肌细胞的胞外囊泡 microRNA 货物及其对内皮的影响

核心信息

• 论文英文标题: Extracellular vesicle microRNA cargoes from intermittent hypoxiaexposed cardiomyocytes and their effect on endothelium
• 期刊: Biochem Bioph Res Co
• 发表年份: 2021
• DOI: 10.1016/j.bbrc.2021.02.034
• PMID/PMCID: 33647794

研究概览

In current study, we attempt to compare the disparity of myocardial EV miRNA components after IH or normoxia treatment and determine whether EVs from IH-treated cardiomyocytes could affect endothelial function. However, the mechanism has not been fully elucidated.

核心发现

Intermittent hypoxia (IH), a main characteristic of obstructive sleep apnea (OSA) syndrome, is an independent risk factor of cardiovascular complications.

However, the mechanism has not been fully elucidated.

Growing evidence has revealed alterations of extracellular vesicle (EV) contents, mostly miRNAs, playing a pathogenic role in cardiovascular complications.

In current study, we attempt to compare the disparity of myocardial EV miRNA components after IH or normoxia treatment and determine whether EVs from IH-treated cardiomyocytes could affect endothelial function.

Echo Biotech 角色

外泌体miRNA测序分析

关联平台: Exoomics®

关联服务与能力: EV miRNA Profiling / Sequencing

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Extracellular vesicle microRNA cargoes from intermittent hypoxiaexposed cardiomyocytes and their effect on endothelium Biochem Bioph Res Co. 2021. DOI: 10.1016/j.bbrc.2021.02.034. PMID/PMCID: 33647794.