来源于“血清和葡萄糖”缺乏的HUCMSC EVs通过增强血管生成促进皮肤伤口愈合
核心信息
- 论文英文标题: Extracellular vesicles derived from "serum and glucose" deprived HUCMSCs promoted skin wound healing through enhanced angiogenesis
- 期刊: Mol Cell Biochem
- 发表年份: 2024
- DOI: 10.1007/s11010-024-05058-1
- PMID/PMCID: 38967721; 9607481
研究概览
In this study, we obtained EVs from normal (N-EVs) and serum- and glucose-deprived (SGD-EVs) human umbilical cord mesenchymal stem cells (HUCMSCs), and showed that SGD-EVs promoted the migration, proliferation, and tube formation of HUVECs in vitro. In vivo experiments utilizing a rat model show that both N-EVs and SGD-EVs boosted angiogenesis of skin defects and accelerated skin wound healing, while treating wounds with SGD-EVs led to faster skin healing and enhanced angiogenesis.
核心发现
Extracellular vesicles (EVs) produced from MSCs were currently considered as a novel therapeutic agent for skin tissue regeneration and repair.
Preconditioning stem cells may activate more molecular pathways and release more bioactive agents.
In this study, we obtained EVs from normal (N-EVs) and serum- and glucose-deprived (SGD-EVs) human umbilical cord mesenchymal stem cells (HUCMSCs), and showed that SGD-EVs promoted the migration, proliferation, and tube formation of HUVECs in vitro.
In vivo experiments utilizing a rat model show that both N-EVs and SGD-EVs boosted angiogenesis of skin defects and accelerated skin wound healing, while treating wounds with SGD-EVs led to faster skin healing and enhanced angiogenesis.
Echo Biotech 角色
外泌体分离NTA鉴定&外泌体miRNA测序分析
关联平台: Exoomics®
关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing
关联产品或试剂: 无明确产品引用
参考文献
原始论文: Extracellular vesicles derived from "serum and glucose" deprived HUCMSCs promoted skin wound healing through enhanced angiogenesis Molecular and cellular biochemistry. 2024. DOI: 10.1007/s11010-024-05058-1. PMID/PMCID: 38967721; 9607481.