EVs miR-205-5p通过广泛下调VEGFA抑制胰腺癌淋巴结转移
核心信息
- 论文英文标题: Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA
- 期刊: J Cancer
- 发表年份: 2025
- DOI: 10.7150/jca.110659
- PMID/PMCID: 40302796; PMC12036096
研究概览
Through miRNA sequencing of plasma extracellular vesicles (EVs) from PDAC patients, for the first time, we identified that plasma EV-miR-205-5p served as a non-invasive biomarker distinguishing lymphatic metastasis status (N0 vs. The inhibition of early lymph node metastasis, including the lymphangiogenic process, may be a novel strategy for PDAC treatment.
核心发现
Pancreatic ductal adenocarcinoma (PDAC) is to become the second leading cause of cancer-related death by 2040.
Many factors contribute to this dilemma, including lymphatic metastasis, which is the primary cause of PDAC metastasis.
The inhibition of early lymph node metastasis, including the lymphangiogenic process, may be a novel strategy for PDAC treatment.
Through miRNA sequencing of plasma extracellular vesicles (EVs) from PDAC patients, for the first time, we identified that plasma EV-miR-205-5p served as a non-invasive biomarker distinguishing lymphatic metastasis status (N0 vs.
Echo Biotech 角色
引用Exosupur分离血浆外泌体，实际提供服务为：血浆外泌体分离表征、miRNA测序分析
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA Journal of Cancer. 2025. DOI: 10.7150/jca.110659. PMID/PMCID: 40302796; PMC12036096.