EVs miR-31-5p通过调节LATS2-Hippo途径和促进胰腺星状细胞分泌SPARC促进胰腺癌化疗耐药
核心信息
- 论文英文标题: Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells
- 期刊: J Extracell Vesicles
- 发表年份: 2024
- DOI: 10.1002/jev2.12488
- PMID/PMCID: 39104296; PMC11300957
研究概览
In this study, we showed that SP1-transcribed miR-31-5p not only targeted LATS2 in pancreatic cancer cells but also regulated the Hippo pathway in PSCs through EV transfer. Gemcitabine-based chemotherapy is still one of the first-line systemic treatments, but chemoresistance occurs in the majority of patients.
核心发现
Pancreatic cancer remains one of the most lethal malignant diseases.
Gemcitabine-based chemotherapy is still one of the first-line systemic treatments, but chemoresistance occurs in the majority of patients.
Recently, accumulated evidence has demonstrated the role of the tumour microenvironment in promoting chemoresistance.
In the tumour microenvironment, pancreatic stellate cells (PSCs) are among the main cellular components, and extracellular vesicles (EVs) are common mediators of cell‒cell communication.
Echo Biotech 角色
Exosupur试剂盒ES9P14e
关联平台: Exoomics®, Research Reagents & Tools
关联服务与能力: Biofluid EV Isolation & Purification, Research Reagent / Product Supply
关联产品或试剂: Exosupur® EV Isolation/Purification Kit
参考文献
原始论文: Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells Journal of Extracellular Vesicles. 2024. DOI: 10.1002/jev2.12488. PMID/PMCID: 39104296; PMC11300957.