在3D重建的全层皮肤模型中MSC EVs调节皮肤衰老生物标志物

核心信息

论文英文标题: Extracellular vesicles modulate skin aging biomarkers in a 3D reconstructed full-thickness skin model
期刊: Front Cell Dev Biol
发表年份: 2026
DOI: 10.3389/fcell.2026.1784998
PMID/PMCID: 41869020; PMC13003219

研究概览

In this study, EVs from adipose-derived stem cells and umbilical cord-derived mesenchymal stem cells (UC-MSCs) were evaluated using both 2D primary skin cells and 3D full-thickness reconstructed skin models. Additionally, miRNA-seq and proteomics of extracellular vesicle contents revealed miRNAs and proteins that may be drivers of the biological activities observed in 3D models, suggesting EVs activate processes associated with skin regeneration.

核心发现

Extracellular vesicles (EVs) are lipid-enveloped nanovesicles rich in microRNAs, proteins and lipids, that serve as potent mediators of intercellular communication.

While EVs have demonstrated pro-regenerative potential in 2D and preclinical models, their impact on skin regeneration and aging processes in 3D reconstructed skin models has remained less explored.

EVs stimulated fibroblast and keratinocyte proliferation, increased epidermal thickness, and enhanced the presence of collagen IV in the dermal-epidermal junction (DEJ) and fibrillin 1 in the extracellular matrix.

Echo Biotech 角色

脐带和脂肪干细胞外泌体分离表征&miRNA测序服务

关联平台: Exoomics®, EV Materials / Reference Materials, Research Reagents & Tools

关联服务与能力: EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing, EV Material / Reference Material Supply

关联产品或试剂: Echo Biotech EV Material (brand/model to verify)

参考文献

原始论文: Extracellular vesicles modulate skin aging biomarkers in a 3D reconstructed full-thickness skin model Frontiers in cell and developmental biology. 2026. DOI: 10.3389/fcell.2026.1784998. PMID/PMCID: 41869020; PMC13003219.