禽致病性大肠杆菌APEC产生的EVs通过TLR4信号激活巨噬细胞促炎反应和中性粒细胞外陷阱NET的形成

核心信息

• 论文英文标题: Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling
• 期刊: Microb Cell Fact
• 发表年份: 2023
• DOI: 10.1186/s12934-023-02171-6
• PMID/PMCID: 37689682; PMC10492386

研究概览

In this study, we investigated the relationships between APEC EVs and immune cells. APEC extracellular vesicles (EVs) may play vital roles in the interaction of the pathogen with its host cells.

核心发现

In this study, we investigated the relationships between APEC EVs and immune cells.

The production and characteristics of the EVs of APEC isolate CT265 were identified.

Toll like receptor 4 (TLR4) triggered the cellular immune responses when it interacted with APEC EVs.

APEC EVs induced a significant release of proinflammatory cytokines in THP-1 macrophages.

Echo Biotech 角色

NTA检测

关联平台: Exoomics®

关联服务与能力: EV Basic Characterization (TEM/NTA/WB)

关联产品或试剂: 无明确产品引用

参考文献

原始论文: Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling Microb Cell Fact. 2023. DOI: 10.1186/s12934-023-02171-6. PMID/PMCID: 37689682; PMC10492386.