纤维网状细胞外泌体是治疗脓毒症急性肾损伤的一种有前景的方法

核心信息

• 论文英文标题: Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury
• 期刊: Kidney Int
• 发表年份: 2024
• DOI: 10.1016/j.kint.2023.12.007
• PMID/PMCID: 38163633

研究概览

To dissect the mechanism underlying the protective role of Exos in S-AKI, we examined the proteins within Exos by mass spectrometry and found that CD5L was the most upregulated protein in FRC-Exos compared to macrophage-derived Exos. Thus, strategies to modify FRC-Exos could be a new avenue in developing therapeutics against kidney injury.

核心发现

Sepsis-induced acute kidney injury (S-AKI) is highly lethal, and effective drugs for treatment are scarce.

Previously, we reported the robust therapeutic efficacy of fibroblastic reticular cells (FRCs) in sepsis.

Here, we demonstrate the ability of FRC-derived exosomes (FRC-Exos) to improve C57BL/6 mouse kidney function following cecal ligation and puncture-induced sepsis.

In vivo imaging confirmed that FRC-Exos homed to injured kidneys.

Echo Biotech 角色

LTH脂锚试剂盒

关联平台: Echosome®, Research Reagents & Tools

关联服务与能力: Targeting Peptide / Surface Modification, Research Reagent / Product Supply

关联产品或试剂: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

参考文献

原始论文: Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury Kidney Int. 2024. DOI: 10.1016/j.kint.2023.12.007. PMID/PMCID: 38163633.